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Enfamil Newborn vs Infant Formula – What is the Difference?

Choosing a formula especially for a newborn can be a tricky business. You need to know what is available and of course which is the best for your child. Enfamil is one of the most well-known brands on the market and they have a suitable formula available for everything from newborn, colic, lactose-free and soy milk. So with this in mind which formula would be best for a newborn Enfamil newborn vs infant formula.


The Main Differences Between Enfamil Newborn vs Infant Formula


  • Enfamil Newborn contains slightly more protein and vitamin D than the infant formula.
  • Enfamil Newborn contains inositol which is considered a building block in brain development.
  • Enfamil Infant contains the fat protein blend of MFGM and DHA which supports cognitive development.


Enfamil Newborn

The Enfamil Newborn comes in a 22.2 ounce reusable tub.  Enfamil Newborn contains a nutrient called inositol which is usually only found in breastmilk. The purpose of this specific nutrient is its brain developing ability. It is considered a building block for your baby’s brain. When you feed your baby with Enfamil newborn you are providing them with the amount of inositol that is available for babies that are exclusively breastfed.

It also contains a dual prebiotic, these nutrients promote the growth of good bacteria in the digestive tract. This is where 70% of the immune system is located. It also includes vitamin C and E to support immune health.

For your little one’s brain development this newborn formula comes with 20mg of omega 3 DHA per 6 fl oz, this is the same as the worldwide average found in breast milk. This unique blend goes on to support brain and eye development.

It has an easy to digest protein blend to ensure it is gentle on your newborn’s tummy.

Enfamil Newborn is also non-GMO, which means that it does not contain genetically engineered ingredients.



Newborn Pros

  • Good to supplement while breastfeeding
  • Gentle on babies tummy
  • non-GMO
  • Good brain development nutrients

Newborn Cons

Enfamil Infant

Enfamil Infant comes in a 20.7 ounce reusable tub. It contains a unique fat protein blend of MFGM and DHA. This fat protein blend has only previously been found in breastmilk and from recent clinical studies it has shown that MFGM and DHA in formula supports cognitive development in babies similar to breastmilk.

It is made with non-GMO ingredients meaning that they have not been genetically engineered in any way. It also provides complete nutrition for your baby up to 12 months old.

Enfamil infant is made with easy to digest proteins to make in gentle on your baby’s tummy. It comes with dual prebiotics to help support immune health.


Infant Pros

  • Unique fat protein blend for brain development
  • non-GMO ingredients
  • Dual prebiotics
  • Gentle on baby’s tummies
  • Suitable up to 12 months

Infant Cons

  • Can cause constipation and gassiness
  • Issues with packaging
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FAQ Enfamil Newborn vs Infant Formula

What is the difference between the powder and liquid versions?

The only difference between the powder and liquid version of the Enfamil is that the liquid version is ready to use and does not require anything added to it, while the powder version requires it to be mixed with water to create a formula.

The powder version is also considerable cheaper than the liquid version.

How many ounces of formula does one tub make?

Each 20.7 ounce tub of Enfamil infant will make approximately 148 fluid ounces of formula when prepared according to the directions on the label.

What is the Protein type in this formula?

The protein type is non-fat milk. It does not state if it is cow or other. It also contains lactose, palm olein, coconut, soy and, high optic sunflower oil.

Is the storage tub BPA free?

All Enfamil storage tubs and pouches are made without using BPA, so they are all BPA free.

Enfamil Newborn vs Infant Formula which is best?

Baby Drinking Forumla from a Bottle

To be honest both of these formulas are great and each one has its own advantages for the specific age group that it is recommended for. For example if you have a newborn who needs as much protein and nutrients that they can get with great brain developing nutrients as well then the Enfamil Newborn would be a good choice. But if you have a 3 month old who is starting to develop cognitive skills then the Enfamil Infant would be the choice for you.

With this in mind, I believe that they are both winners! Enfamil Newborn and Enfamil Infant are equally good at the job they were developed to do.

Related Article: Enfamil vs Similac – Which Formula is Best for your Baby?

Switching from Newborn to Infant Formula

The recommended age for newborn formula is 0-3 months. After this time you will need to consider switching your baby on to an all round formula. This switch can take place as soon as your baby turns 3 months old or you may choose to wait a few weeks.

Either way, there is no ideal way of switching from newborn to infant formula. You must be prepared that your once content and peaceful baby may become fussy and miserable. Weaning needs to be carried out gradually over a 7 day period. This will give your baby the greatest chance of a smooth transition.


Things to look out for when you are transitioning from newborn formula to infant formula are that your baby may become fussy, they may start waking through the night for feeding or even a diaper change when previously they had slept soundly all night. They may have gas and may even be constipated or have diarrhea.

The cause of these issues may be the slight changes in nutrients. Things should settle down in a few days and your happy content baby will return!

If you continue to have any issues then it would be best to consult your pediatrician for advice.